Whilst reduced-depend MBL almost never progresses to CLL, high-count MBL progresses to CLL necessitating therapy in a amount of one% to two% a year. High-depend MBL is distinguished from Rai 0 CLL based upon whether the B-cell rely is earlier mentioned or beneath 5 × 109/L. Whilst persons with equally superior-rely MBL and CLL Rai stage 0 are at i